Protein misfolding and human diseases (2015/2016)

Course code
4S003664
Name of lecturer
Paola Dominici
Coordinator
Paola Dominici
Number of ECTS credits allocated
6
Academic sector
BIO/10 - BIOCHEMISTRY
Language of instruction
English
Period
II semestre dal Mar 1, 2016 al Jun 10, 2016.

Lesson timetable

II semestre
Day Time Type Place Note
Monday 8:30 AM - 11:30 AM lesson Lecture Hall L from Apr 18, 2016  to Jun 10, 2016
Tuesday 12:30 PM - 2:30 PM lesson Lecture Hall H  

Learning outcomes

This course aims to provide information on conformational disease, protein quality control system, chaperone,inherited disorders.
In particular, students will gain familiarity with PRINCIPLES OF PROTEIN MISFOLDING;PROTEIN MISFOLDING DISEASE;MEDICAL ASPECTS OF DISEASE: DIAGNOSIS AND CURRENT THERAPIES

Syllabus

PRINCIPLES OF PROTEIN MISFOLDING
Why Proteins Misfold
Endoplasmic Reticulum Stress and Oxidative Stress:
Mechanisms and Link to Disease
Role of Molecular Chaperones in Protein Folding
Kinetic Models for Protein Misfolding and Association
Autophagy: An Alternative Degradation Mechanism
for Misfolded Proteins
Role of Posttranslational Modifications in Amyloid Formation
Caenorhabditis elegans as a Model System to Study the
Biology of Protein Aggregation and Toxicity
Animal Models to Study the Biology of Amyloid-b
Protein Misfolding in Alzheimer Disease

PROTEIN MISFOLDING DISEASE: GAIN-OF-FUNCTION AND LOSS-OF-FUNCTION DISEASES
Alzheimer Disease: Protein Misfolding, Model Systems,
and Experimental Therapeutics
Prion Disease Therapy
Misfolding and Aggregation in Huntington Disease
Systemic Amyloidoses
Copper–Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis
Alpha-1-Antitrypsin Deficiency
Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease
Cataract as a Protein-Aggregation Disease

MEDICAL ASPECTS OF DISEASE: DIAGNOSIS AND CURRENT THERAPIES
Imaging of Misfolded Proteins
Diagnosis of Systemic Amyloid Diseases
Identification of Biomarkers for Diagnosis of Amyloid Diseases: Quantitative Free Light-Chain Assays
Current and Future Therapies for Alzheimer Disease
Current Therapies for Light-Chain Amyloidosis
Identifying Targets in a-Synuclein Metabolism to Treat
Parkinson Disease and Related Disorders

Assessment methods and criteria

Scritto. Domande aperte su argomenti del programma.

STUDENT MODULE EVALUATION - 2015/2016