| Activity | Credits | Period | Academic staff | Timetable |
|---|---|---|---|---|
| Teoria | 5 | II semestre | Daniela Cecconi | |
| Laboratorio | 1 | II semestre | Daniela Cecconi |
Module:
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Clinical proteomics is the science that aims to develop technologies for the treatment of patients through the analysis of proteomes of healthy and sick cells. This research area aimed to identify proteins that can be used as early markers in blood, urine, or tissues of cancer patients, or that may predict response to therapy or the relapse after treatment.
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Analytical proteomics (LM9+LM7):
1. Introduction.
2. Sample preparation.
3. Gel-based separation.
4. 2D gel Image analysis.
5. Gel-free separation.
6. Pre-fractionation of low abundance proteins.
7. Analysis of proteins/peptides by Mass Spectrometry.
8. Analysis of proteins/peptides by Tandem Mass Spectrometry.
9. Analysis of mass spectra and database search for protein identification.
10. Differential and Quantitative proteomics.
11. Characterization of post-translational modifications.
12. Proteomics in agro-food area.
Clinical proteomics (LM9):
13. Cancer (I).
14. Cancer (II).
15. Using proteomics to study mechanism of pharmacological action of new drugs
16. Cardiac Disease.
17. Vascular Disease and Hypertension.
18. Hemochromatosis and Intrauterine growth retardation
19. Bacterial and viral infections.
20. Autoimmune disease.
RECOMMENDED TEXT BOOKS:
“Introducing Proteomics: From concepts to sample separation, mass spectrometry and data analysis” Josip Lovric, Oxford : Wiley-Blackwell, (textbook) (LM7, LM9)
“Clinical Proteomics: From Diagnosis to Therapy” Jennifer E. Van Eyk (Editor), Michael J. Dunn (Editor) Wiley & Sons Ltd, ISBN: 978-3-527-31637-3 Hardcover (LM9)
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LM7: written
LM9: mini oral presentation in group + written
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