Bioreactors (2008/2009)

Course partially running

Course code
4S00307
Credits
5
Coordinator
Francesco Fatone
Other available courses
Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff
Teoria 4 ING-IND/25-CHEMICAL PLANTS 1° Sem Francesco Fatone
Laboratorio 1 ING-IND/25-CHEMICAL PLANTS 1° Sem Francesco Fatone

Learning outcomes

Module: Teoria
-------
Further to the skills regarding the Biochemical Plants, the Bioreactors course gives the fundamentals and the kinetic tools for a quantitative approach to the bioprocess design and management. It takes into account the different bioreactors configurations usually adopted for the industrial productions and/or treatments. Moreover, elements of bioreactor engineering, such as mixing, aeration, monitoring and controls, will be deal with.


Module: Laboratorio
-------
Aim of the course is to give the adequate quantitative/practical support for the determination of main kinetic parameters concerning bioprocessing. This aim is achieved by both calculation examples and lab exercises. This module is an actual integrative part of the theoretical module “Bioreactors”

Syllabus

Module: Teoria
-------
1. Basic elements of enzyme reaction kinetics
a. Michaelis-Menten Kinetics
b. Enzyme inhibition
c. Substrate inhibition
d. Effect of the temperatue
e. Heterogeneous reactions in bioprocessing and mass transfer phenomena
f. Cell growth kinetics

2. Types of bioreactors: modelling, design and management
a. Generalities about ideal chemical reactors
b. Ideal flow Complete-Mix Reactors (CSTR)
c. Role of diffusion in bioprocessing
d. CSTRs in series
e. Single CSTR with biomass recycle
f. Plug-flow reactors
g. Batch reactors
h. Fed-batch reactors
i. Stability operation for bioreactors
j. Elements of bioreactors engineering: construction materials, monitoring and control

3. Reactor mixing and aeration
a. Fundamentals
b. Mass and momentum transfer
c. Aeration without mechanical mixing and effect of: (a) operating conditions, (b) reactor geometry,(c) flux directions
d. Effect of mechanical mixing on mass transfer



Module: Laboratorio
-------
The course will deal with lab experiments to measure and calculate the bioreaction rates and the kinetic parameters. Also, the theoretical topics concerning “Bioreactors” will be deal with solving calculation problems

Assessment methods and criteria

Module: Teoria
-------
The exam consists of one or two written parts, in case of midterm examination. In the written exams the student has both to solve quantitative problems and to answer to multiple choice questions regarding theoretical aspects. If necessary, also a final oral exam could be required.


Module: Laboratorio
-------
The exam consists of a report concerning the lab experiment(s). This document will be taken into account for the final evaluation of the module “Bioreactors”.

Reference books
Author Title Publisher Year ISBN Note
Pauline M. Doran Bioprocess Engineering Principles Academic Press 1995 0-12-220855-2

Studying

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